Brain Synapses

Ketamine Infusion Therapy: Repairing Damaged Synapses and Neuronal Connections in the Brain

Ketamine, a dissociative anesthetic primarily used for pain management and anesthesia, has garnered significant attention in recent years for its potential therapeutic applications in psychiatry and neurology. Among these applications is treating conditions characterized by damaged synapses and disrupted neuronal connections in the brain. Ketamine Infusion Therapy, has shown remarkable promise in repairing damaged synapses and neuronal connections, offering new hope to individuals suffering from a range of neuropsychiatric disorders.

Synapses are the junctions where neurons communicate with each other, enabling the transmission of signals in the brain. These connections are essential for various cognitive and emotional processes. When damaged or weakened, it can lead to a wide range of neurological and psychiatric disorders, including depression, anxiety, post-traumatic stress disorder (PTSD), and chronic pain syndromes. The mechanisms underlying the therapeutic potential of Ketamine Infusion Therapy for repairing damaged synapses and neuronal connections involve its effects on glutamate, neuroplasticity, and neuroinflammation.

Glutamate is the brain’s primary excitatory neurotransmitter, crucial in synaptic transmission and plasticity. Dysregulation of glutamate signaling is often implicated in neuropsychiatric disorders, leading to synaptic dysfunction and neuronal damage. Ketamine acts as an antagonist of the N-methyl-D-aspartate (NMDA) receptor, a subtype of glutamate receptor. By blocking NMDA receptors, Ketamine temporarily disrupts abnormal glutamate signaling patterns, effectively “resetting” synapses and allowing them to reestablish healthy communication between neurons. This transient blockade of NMDA receptors provides a window of opportunity for synaptic repair and reconnection.

Moreover, Ketamine promotes neuroplasticity, the brain’s ability to reorganize its structure and function in response to experiences and environmental changes. This process is essential for learning, memory, and brain injury or disorder recovery. Ketamine appears to enhance neuroplasticity through several mechanisms. One of the critical pathways involves the activation of the mammalian target of rapamycin (mTOR), a cellular signaling pathway associated with neuronal growth and synapse formation. By stimulating mTOR activity, Ketamine facilitates the development of new synaptic connections and the strengthening of existing ones, aiding in the repair of damaged neural networks.

Furthermore, Ketamine may alleviate synaptic damage by reducing neuroinflammation, a process often implicated in the pathogenesis of neuropsychiatric disorders. Inflammatory responses in the brain can release pro-inflammatory cytokines and oxidative stress, which can damage synapses and impair neuronal connectivity. Ketamine has been shown to possess anti-inflammatory properties, inhibiting the release of inflammatory mediators and attenuating neuroinflammation. By mitigating neuroinflammatory processes, Ketamine may contribute to preserving and restoring synaptic function.

To understand how Ketamine Infusion Therapy repairs damaged synapses and neuronal connections, examining its effects on specific neuropsychiatric conditions is crucial.

1. **Depression**: Major depressive disorder (MDD) is associated with synaptic atrophy and impaired connectivity in brain regions such as the prefrontal cortex and hippocampus. Ketamine’s rapid antidepressant effects have been attributed to its ability to increase synaptic connectivity in these regions rapidly. It does so by promoting the formation of new dendritic spines and synapses, effectively reversing the structural deficits seen in depression.

2. **Anxiety Disorders**: Anxiety disorders often involve dysfunctional communication between brain regions responsible for emotional processing and regulation. Ketamine may alleviate anxiety symptoms by enhancing synaptic plasticity in these regions, allowing for more adaptive responses to stress and threat-related stimuli.

3. **Post-Traumatic Stress Disorder (PTSD)**: PTSD is characterized by hyperactive fear circuits and disrupted emotional processing. Ketamine may help repair damaged synapses and neuronal connections within these circuits, potentially reducing the emotional reactivity and intrusive memories associated with PTSD.

4. **Chronic Pain Syndromes**: Chronic pain conditions, such as complex regional pain syndrome (CRPS) and fibromyalgia, can lead to central sensitization and altered pain processing in the brain. Ketamine’s analgesic properties may be partly due to its ability to normalize synaptic function in pain-related brain regions, reducing the perception of pain.

In clinical practice, Ketamine Infusion Therapy typically involves administering a subanesthetic dose of Ketamine intravenously. The effects are often felt within minutes to hours and can last several days to weeks, depending on the individual and the condition being treated. The therapy is typically administered in a controlled and supervised medical setting, ensuring patient safety and minimizing potential adverse effects.

It’s important to note that while Ketamine Infusion Therapy shows remarkable promise in repairing damaged synapses and neuronal connections, it is not a panacea. Individual responses to Ketamine can vary, and the long-term effects and optimal treatment protocols are still subjects of ongoing research.

Ketamine Infusion Therapy offers a novel and exciting approach to repairing damaged synapses and neuronal connections in the brain. Its multifaceted effects on glutamate signaling, neuroplasticity, and neuroinflammation provide a unique opportunity to treat a range of neuropsychiatric disorders characterized by synaptic dysfunction. While further research is needed to refine treatment protocols and ensure long-term safety, Ketamine Infusion Therapy represents a promising avenue for individuals seeking relief from conditions that have thus far proven resistant to conventional treatments. As our understanding of the underlying mechanisms continues to evolve, Ketamine may play an increasingly pivotal role in the field of neuropsychiatry, offering renewed hope for those in need.

If you are interested in learning more, click here

Ketamine Infusion Therapy Experience

The Ketamine Infusion Therapy Experience : What to Expect

Many want to know what to expect when it comes to the Ketamine Infusion Therapy Experience. In recent years, the administration of intravenous low-dose ketamine has been found to be surprisingly effective in rapidly improving the symptoms of depression, posttraumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), and other mental health conditions, as well as chronic pain syndromes. This effect is supported by myriad studies conducted at reputable research centers from 2000 to the present.

Ketamine has been shown to improve symptoms of depression in as little as several hours after the first treatment. This lifting of the depressive symptoms seems to last anywhere from several days to weeks or months and typically lasts longest after a series of six infusions over a two-week period. Single-dose “booster” treatments at a period of two weeks to months after the initial infusion have been shown to prolong the antidepressant effect of the medication in many patients.

In 2014, Thomas Insel, former Director of the National Institute of Mental Health, stated that, “Recent data suggest that ketamine, given intravenously, might be the most important breakthrough in antidepressant treatment in decades.”

The patient experience of ketamine infusion therapy treatment can vary depending on the individual, but some common themes exist. When it comes to the Ketamine Infusion Therapy experience, here is what you can expect:

  • Pre-treatment: Before the infusion, the patient will typically meet with a doctor or nurse practitioner to discuss their medical history and mental health condition. They will also be given a physical exam and have their vital signs taken. The doctor will then explain the procedure and answer any patient questions.
  • Infusion: The infusion itself typically takes about an hour. The patient will be seated or lying down in a comfortable recliner. An IV will be inserted into their arm, and the ketamine will be administered slowly over time. During the infusion, the patient may experience a variety of sensations, including:
    • A feeling of dissociation or detachment from their body and surroundings
    • Altered perceptions, such as seeing things that are not there or hearing voices
    • A sense of euphoria or well-being
    • Drowsiness or fatigue
    • Nausea or vomiting

Interestingly, low-dose ketamine does not typically cause a sense of sedation or mental dulling, and many patients report that they are mentally quite sharp and can review and work through their thoughts and feelings clearly and calmly for the first time in their lives.

  • Post-treatment: After the infusion, the patient will be monitored for a few hours to ensure they are safe. They may be given anti-nausea medication as well as fluids. Most patients are able to go home after the infusion.

Although the intensity of the effects of ketamine wears off quickly, there may be some sense of imbalance and slowing of reaction times for a few hours. It is advised that patients should not drive or operate power machinery following treatment. Some patients experience immediate relief from their symptoms, while others may need multiple infusions before seeing a benefit.

The most common side effects of the ketamine infusion therapy experience are drowsiness, lightheadedness, dizziness, and nausea. These side effects are usually mild and go away on their own. More serious side effects are rare, but they can include:

  • Hallucinations
  • Confusion
  • High blood pressure
  • Low blood pressure
  • Seizures

Here are some additional things to keep in mind about the patient experience of ketamine infusion therapy:

  • The environment in which the infusion takes place can significantly impact the patient’s experience. A comfortable, relaxing environment can help to reduce anxiety and make the experience more enjoyable.
  • The patient’s expectations can also play a role in their experience. If the patient is expecting a negative experience, they are more likely to have one. It is essential to set realistic expectations and to be open to the possibility of a positive outcome.
  • The patient’s relationship with the healthcare team can also impact their experience. A supportive and understanding team can make the experience more comfortable and less anxiety-provoking.

If you are considering ketamine infusion therapy, it is vital to research and find a reputable clinic with experienced staff. It would be best to talk to your doctor about your unique circumstances to ensure ketamine is the best treatment for you.

At Tranquility Ketamine, ketamine is given intravenously, using National Institute of Mental Health dosing protocols. These protocols vary depending on whether you are being treated for mental health or chronic pain syndromes. Typically, mental health disorders begin with a treatment of 0.5 mg/kg infused intravenously over 40 minutes, followed by 45 minutes of relaxation while the medication wears off. However, we understand that this NIH dosing protocol was decided arbitrarily and that dosage adjustments, both up and down, may be necessary for maximum effect and comfort, depending on the individual.

Our team of doctors and nurses understand the frustrations of patients who have tried conventional therapies with little or no success. That’s why every aspect of ketamine infusion treatment at Tranquility Ketamine has been thoughtfully designed to be stress-free, relaxing, and encouraging. From streamlined scheduling to infusions performed by friendly and caring staff to an unhurried and restful post-infusion period, we ensure your ketamine treatment experience is positive and productive.

For more information, please call (505) 639-4973 or visit

brain depicting ketamine infusion therapy effects

Finding Relief through Ketamine Infusion Therapy: Who Can Benefit the Most?

In recent years, Ketamine Infusion Therapy has emerged as a promising breakthrough in treating various mental health conditions. Traditionally known for its anesthetic properties, ketamine has now found a new role as a powerful tool in managing treatment-resistant depression, anxiety disorders, and chronic pain. This innovative therapy has shown significant potential to help those who have been struggling with conventional treatment methods. In this blog, we’ll explore who can benefit the most from Ketamine Infusion Therapy and how it can be a game-changer in their lives.

Individuals with Treatment-Resistant Depression:

Depression affects millions of people worldwide, and while effective treatments are available, some individuals experience treatment-resistant depression. These individuals have tried multiple antidepressant medications and therapies with little to no relief from their symptoms. Ketamine Infusion Therapy offers new hope for these patients. The infusion works by targeting the brain’s glutamate system, rapidly alleviating depressive symptoms, often within hours or days after treatment. This quick and potent response is a lifeline for those who have felt hopeless and helpless for too long.

Patients with Severe Anxiety Disorders:

Anxiety disorders can be debilitating and significantly impact a person’s ability to lead a normal life. For patients who have not responded well to traditional anxiolytic medications or psychotherapy, Ketamine Infusion Therapy can be a transformative option. The treatment helps calm hyperactive neural circuits responsible for anxiety, providing immediate relief and enabling patients to regain control over their lives. Moreover, the effects of ketamine on anxiety are longer-lasting compared to other conventional treatments, which often require weeks to months to take effect.

Veterans and PTSD Sufferers:

Post-Traumatic Stress Disorder (PTSD) is a severe condition often experienced by veterans and survivors of traumatic events. For many, conventional treatments might not offer the desired relief from their symptoms. Ketamine Infusion Therapy presents a glimmer of hope for these individuals. The therapy helps in the formation of new neural connections in the brain, essentially rewiring the traumatic memories associated with PTSD. Veterans and survivors may find relief from intrusive thoughts, nightmares, and hypervigilance, allowing them to lead a more fulfilling life.

Chronic Pain Patients:

Chronic pain can be physically and emotionally draining, affecting the individual’s physical and mental health. Ketamine’s analgesic properties can provide significant pain relief for certain chronic pain conditions, such as fibromyalgia, neuropathic pain, and complex regional pain syndrome (CRPS). By targeting pain receptors in the brain, ketamine disrupts pain signals and provides respite to those who have been suffering for extended periods.

Individuals with Suicidal Ideation:

For individuals struggling with suicidal thoughts, finding an effective and immediate intervention is crucial. Ketamine Infusion Therapy has shown remarkable success in rapidly reducing suicidal ideation. The treatment can break the cycle of hopelessness, allowing individuals to seek further psychological support and long-term solutions.

Cancer Patients:

Dealing with a cancer diagnosis and undergoing rigorous treatments can significantly affect a patient’s mental health. Ketamine Infusion Therapy can aid cancer patients in managing the emotional distress and anxiety associated with their condition. Additionally, ketamine’s potential to alleviate neuropathic pain can especially benefit those experiencing chemotherapy-induced peripheral neuropathy.

Those Seeking Rapid Relief:

One of the most significant advantages of Ketamine Infusion Therapy is its rapid onset of action. Unlike traditional antidepressants that may take weeks to start working, ketamine can show improvement in symptoms within hours or days. This aspect of the treatment makes it highly valuable for individuals who require immediate relief, such as students preparing for exams, professionals dealing with high-pressure situations, or those struggling with acute grief.

Ketamine Infusion Therapy has brought newfound hope to many individuals battling debilitating mental health conditions and chronic pain. Its ability to offer rapid relief to those who have not responded to conventional treatments makes it a beacon of hope in psychiatry and pain management. As research and understanding of ketamine’s therapeutic potential continue to grow, more people can benefit from this revolutionary treatment. If you or a loved one are among those who have struggled to find relief through traditional methods, Ketamine Infusion Therapy might be the transformative solution you’ve been searching for. Always consult a qualified healthcare professional to determine if this treatment is appropriate for your condition.


For more information on treatment and costs, contact Tranquility Ketamine at (505) 639-4973 or visit


ketamine infusion therapy

The Benefits of Ketamine Infusion Therapy: A Powerful Treatment for Depression and Anxiety

In recent years, the use of ketamine infusion therapy has gained significant attention as a potential treatment for depression and anxiety. Backed by scientific research and real-world analysis, ketamine infusion therapy has emerged as a powerful tool in the fight against these debilitating mental health conditions. Here we will explore the benefits of ketamine infusion therapy, drawing insights from two notable sources, including a study published on PsyPost and insights from Stanford Neuroscience.

Real-World Analysis Confirms Efficacy

A recent study featured on PsyPost highlights the real-world analysis of ketamine infusion therapy, confirming its effectiveness as a treatment for depression and anxiety. The study, conducted on a large scale, showed promising results for patients who had previously not responded well to traditional treatments. Ketamine infusion therapy was found to produce significant improvements in depressive symptoms, as well as reductions in anxiety levels.

Rapid and Long-lasting Relief

One of the key benefits of ketamine infusion therapy is its ability to provide rapid relief from depressive symptoms. Unlike traditional antidepressant medications, which may take weeks or even months to take effect, ketamine infusion therapy has been shown to have a much quicker onset of action. This rapid relief can be particularly beneficial for individuals experiencing severe depression or anxiety, where immediate intervention is crucial.

Moreover, the effects of ketamine infusion therapy have been reported to be long-lasting. While traditional antidepressant medications often require continuous use to maintain their benefits, ketamine infusion therapy has demonstrated sustained relief even after treatment completion. This aspect is particularly encouraging for individuals who have struggled with treatment-resistant depression, offering them a glimmer of hope in finding lasting relief.

Transformative Potential

According to insights from Stanford Neuroscience, ketamine infusion therapy has been described as “nothing less than transformational” for people suffering from severe depression. Traditional treatments have limitations, and some individuals may find themselves trapped in ineffective interventions. Ketamine infusion therapy, however, has shown great promise in breaking this cycle and providing a fresh start for those who have exhausted other options.

By targeting the glutamate system in the brain, ketamine works in a fundamentally different way compared to traditional antidepressants. This novel approach offers new avenues of treatment, especially for individuals who have not responded well to other medications or therapies. The potential to transform lives and alleviate the suffering of those with severe depression cannot be understated.

Improved Quality of Life

Beyond its impact on depressive symptoms, ketamine infusion therapy has been found to enhance the overall quality of life for individuals suffering from depression and anxiety. Studies have shown that this treatment can lead to improvements in sleep patterns, cognitive function, and social functioning. By alleviating the burden of depressive symptoms, ketamine infusion therapy enables individuals to regain control over their lives and engage more fully in daily activities.

Safety and Tolerability

Ketamine infusion therapy has also shown favorable safety and tolerability profiles. The treatment is administered under close medical supervision to ensure its safe usage in a clinical setting. While side effects may occur, they are generally mild and transient, including nausea, dizziness, and blurred vision. The well-established safety profile of ketamine infusion therapy further supports its potential as a viable treatment option.

The benefits of ketamine infusion therapy for treating depression and anxiety are increasingly being recognized in the scientific community. Real-world analysis and research studies consistently confirm its efficacy, rapid relief, and long-lasting effects. Moreover, ketamine infusion therapy has the potential to be transformative for individuals suffering from severe depression, providing hope and a fresh start. With improved quality of life and a favorable safety profile, ketamine infusion therapy offers a promising path forward in the treatment of these debilitating mental health conditions.

For more information on treatment and costs, contact Tranquility Ketamine at (505) 639-4973 or visit

graphic of PTSD brain concept

Finding Relief and Hope: The Transformative Benefits of Ketamine Infusion Therapy for PTSD

Next month (June) is PTSD Awareness Month. As a clinic specializing in depressive mood disorders, PTSD being one of them, we thought it was essential to look at how Ketamine Infusion Therapy can help. Post-Traumatic Stress Disorder (PTSD) can profoundly impact an individual’s mental health, relationships, and overall quality of life. Fortunately, advancements in medical science have led to innovative treatments that offer renewed hope for individuals struggling with PTSD. One such groundbreaking therapy is Ketamine Infusion Therapy, which has shown remarkable benefits in alleviating the symptoms of PTSD. 

Understanding PTSD:

Post-Traumatic Stress Disorder is a mental health condition that can develop after experiencing or witnessing a traumatic event. The symptoms may include vivid flashbacks, nightmares, severe anxiety, insomnia, and emotional distress. Conventional treatments, such as therapy and medication, have proven effective for many, but some individuals continue to experience distressing symptoms despite these interventions. This is where Ketamine Infusion Therapy comes into play.

The Promise of Ketamine Infusion Therapy:

Ketamine, a dissociative anesthetic initially developed for use in surgery, has gained recognition in recent years for its potential to treat various mental health conditions, including PTSD. 

Scientific Evidence:

Recent studies have supported the efficacy of Ketamine Infusion Therapy in reducing the symptoms of PTSD. For example, published on January 5, 2021, in the American Journal of Psychiatry, it was the first randomized, controlled trial of repeated ketamine administration for chronic PTSD. It suggests ketamine may be a promising treatment for PTSD patients. 

“Our findings provide insight into the treatment efficacy of repeated ketamine administration for PTSD, an important next step in our quest to develop novel pharmacologic interventions for this chronic and disabling disorder, as a large number of individuals are not sufficiently helped by currently available treatments,” says Adriana Feder, MD, Associate Professor of Psychiatry at the Icahn School of Medicine at Mount Sinai and lead author of the study. “The data suggests repeated IV ketamine is a promising treatment for people who suffer from PTSD and provides evidentiary support to warrant future studies to determine how we can maintain this rapid and robust response over time.”

Imaging analysis was conducted on the participants in a follow-up to the above study. The team analyzed detailed brain imaging data of individuals with chronic PTSD treated in the clinical trial with ketamine. Results suggest that improvements in PTSD symptoms observed in the trial were related to specific ketamine-induced changes in connectivity between several brain regions.

How Ketamine Works:

Ketamine works differently from traditional antidepressants by targeting the brain’s glutamate system, a neurotransmitter involved in mood regulation. It enhances the growth of new connections between brain cells, leading to improved neural pathways and enhanced emotional resilience. This unique mechanism of action allows for rapid relief from symptoms, often within hours or days, compared to the weeks or months required for traditional treatments to take effect.

Minimal Side Effects:

Ketamine Infusion Therapy is generally well-tolerated, with minimal side effects reported. Patients may experience mild dissociation during the infusion, which is typically temporary and subsides shortly after the treatment. 

Long-Term Relief and Enhanced Well-being:

One of the most promising aspects of Ketamine Infusion Therapy is its potential to provide lasting relief. While the number of treatments required may vary from person to person, many patients report a significant reduction in PTSD symptoms that begin immediately after treatment and can last weeks. With ongoing treatment, relief enables individuals to regain control of their lives, rebuild relationships, and experience an improved overall sense of well-being.

For individuals grappling with the distressing symptoms of PTSD, Ketamine Infusion Therapy can offer a beacon of hope. Backed by scientific research, this innovative therapy can bring transformative relief, allowing individuals to reclaim their lives from the grip of PTSD. If you are seeking a path toward healing and renewed well-being, consider exploring the possibilities of Ketamine Infusion Therapy as a powerful tool in your journey toward recovery.

For more information on treatment and costs, contact Tranquility Ketamine at (505) 639-4973 or visit


unlocking the benefits of Ketamine infusion therapy

“Understanding Ketamine Treatment: Benefits, Risks, and Follow-Up Care for Mental Health”

Ketamine, a powerful anesthetic drug, has gained attention in recent years for its potential to treat various mental health conditions, including depression, anxiety, and PTSD. While ketamine treatment infusions are still relatively new, studies have shown promising results for those who have failed to respond to traditional treatment options. However, many still have questions about how ketamine works, what to expect during treatment, and how to maintain the benefits over time.

First and foremost, it’s crucial to understand how a ketamine treatment works in the brain. While the exact mechanisms are still being studied, it’s believed that ketamine works by activating specific receptors in the brain that promote the growth of new neural connections. This process, known as neuroplasticity, is thought to be responsible for the rapid and long-lasting effects of ketamine on mood and anxiety.

During a ketamine infusion, a small dose of the drug is administered intravenously for about 40 minutes. Patients typically experience a sense of relaxation and dissociation; some may even have visual or auditory hallucinations. These effects usually wear off within a few hours of the infusion, and patients are typically able to resume their normal activities the next day.

While many people experience immediate relief from symptoms after a single ketamine infusion, most patients require a series of treatments to achieve long-lasting results. The exact number and frequency of infusions will depend on the individual and the severity of their condition. Still, most patients receive a series of six treatments over two to three weeks.

One of the unique aspects of ketamine treatment is the importance of follow-up care. While the effects of a single infusion can be profound, it’s essential to continue working with a mental health professional to ensure that the benefits are maintained over time. This may include regular therapy sessions, medication management, and lifestyle changes to support mental wellness.

One of the most common concerns patients have about ketamine treatment is the potential for side effects. While ketamine is generally safe when administered by a trained medical professional, there are some risks to consider. These may include nausea, dizziness, dissociation during the infusion, and the potential for abuse or addiction if misused.

However, the risks of ketamine treatment are generally considered low compared to the potential benefits. For many patients who have struggled with treatment-resistant mental health conditions, ketamine offers a new hope for relief and improved quality of life.

If you’re considering ketamine treatment, it’s important to research and find a reputable provider with experience administering the drug for mental health conditions. Ask questions about the provider’s training and experience, as well as their approach to follow-up care and patient support.

It’s also important to be open and honest with your mental health provider about your medical history, any medications you’re currently taking, and any concerns or questions you may have about the treatment process. Then, by working together as a team, you and your provider can develop a customized treatment plan that meets your unique needs and helps you achieve lasting mental wellness.

In conclusion, ketamine treatment offers a promising new approach to treating treatment-resistant mental health conditions like depression, anxiety, and PTSD. While the treatment process may be unfamiliar to many patients, it’s important to remember that you’re not alone. With the support of a trusted mental health provider and a commitment to follow-up care, ketamine treatment can be a powerful tool for achieving lasting mental wellness and improved quality of life.


Tranquility Ketamine is a Ketamine Infusion Therapy clinic in Albuquerque, New Mexico. Founded by two experienced emergency room physicians with over 50 years combined practice administering ketamine in the emergency department, the clinic provides effective treatments for depression, PTSD (posttraumatic stress disorder), chronic pain, OCD (obsessive-compulsive disorder), anxiety, stress, and burnout in comfortable private rooms.


  1. “Ketamine Infusions Show Promise as a Treatment for Depression” by Harvard Health Publishing
  2. “Ketamine Infusions for Treatment-Resistant Depression: A Series of 28 Patients Treated Weekly or Twice Weekly in an Outpatient Setting” by The Journal of Neuropsychiatry and Clinical Neurosciences
  3. “Ketamine for Depression: A Review of Its Pharmacodynamic and Pharmacokinetic Properties and Patient Response Rates in Clinical Trials” by The Journal of Clinical Psychiatry
  4. Ketamine Treatment for Depression: Opportunities and Challenges” by The National Institute of Mental Health
  5. “Guideline Watch: Practice Guideline for the Treatment of Patients with Major Depressive Disorder” by American Psychiatric Association

Ketamine Infusion Therapy: The Promising Alternative to Opioids for Chronic Pain Relief

Chronic pain is a widespread problem that affects millions of people worldwide. Various conditions, such as arthritis, fibromyalgia, cancer, and nerve damage, can lead to a chronic pain diagnosis. Unfortunately, the treatment of chronic pain can be a challenging and complex process, and traditional pain management approaches such as opioids have many drawbacks. In recent years, ketamine infusion therapy has emerged as a promising alternative to Opioids for the treatment of chronic pain. This blog post will explore why ketamine infusion therapy is better for chronic pain than opioids.

What are opioids, and how do they work?

Opioids are a class of drugs that are used to treat moderate to severe pain. They work by attaching to specific receptors in the brain and spinal cord, reducing the perception of pain. Opioids are effective painkillers, but they also have significant drawbacks. Opioids can be highly addictive, and prolonged use can lead to tolerance, dependence, and addiction. They can also cause a wide range of side effects, including nausea, constipation, drowsiness, and respiratory depression. In addition, long-term use of opioids can damage the liver, kidneys, and other organs.

What is ketamine infusion therapy?

Ketamine infusion therapy involves the administration of low doses of ketamine, a dissociative anesthetic, into the bloodstream. The therapy has been used for decades as an anesthetic in surgical procedures, but it is only in recent years that its potential as a treatment for chronic pain has been recognized. Ketamine is believed to work by blocking NMDA receptors in the brain, which are involved in the perception of pain.

Advantages of ketamine infusion therapy over opioids for chronic pain

1. Ketamine is not addictive.

One of the most significant advantages of ketamine infusion therapy over opioids is that it is not addictive. While opioids can be highly addictive, ketamine does not produce the same level of dependence. Ketamine does not activate the same reward pathways in the brain as opioids, meaning there is little risk of addiction or abuse.

Ketamine does not cause respiratory depression.

Another significant advantage of ketamine infusion therapy is that it does not cause respiratory depression, a potentially life-threatening side effect of opioids. Respiratory depression occurs when opioids suppress the central nervous system, leading to decreased breathing rate and depth. This can cause oxygen levels in the blood to drop, which can be fatal. Ketamine does not suppress the central nervous system to the same extent as opioids, which means that it does not cause respiratory depression.

2. Ketamine is effective for neuropathic pain.

Neuropathic pain, which is caused by damage to the nerves, is notoriously difficult to treat with opioids. Ketamine, on the other hand, is effective in the treatment of neuropathic pain. Ketamine blocks NMDA receptors in the brain, which are involved in the transmission of pain signals. This means that ketamine can be an effective treatment for chronic neuropathic pain.

3. Ketamine has fewer side effects than opioids.

Opioids can cause a wide range of side effects, including nausea, constipation, drowsiness, and cognitive impairment. Ketamine, on the other hand, has fewer side effects than opioids. The most common side effects of ketamine infusion therapy are mild and include dissociation, dizziness, and changes in perception. These side effects usually resolve quickly after the infusion is stopped.

4. Ketamine has a rapid onset of action.

Another advantage of ketamine infusion therapy over opioids is its rapid onset of action. Ketamine is administered intravenously, which means that it enters the bloodstream quickly and starts to work within minutes. This makes it an effective option for patients who need rapid pain relief.


In summary, ketamine infusion therapy is a promising alternative to opioids for the treatment of chronic pain. Ketamine is not addictive, does not cause respiratory depression, is effective for neuropathic pain, has fewer side effects than opioids, and has a rapid onset of action. While ketamine infusion therapy is not appropriate for all patients, it should be considered a treatment option for those struggling with chronic pain who have not responded to traditional pain management approaches. As always, patients should consult with their healthcare provider to determine if ketamine infusion therapy is right for them.


To learn more about this innovative treatment, click here or call 505-639-4973


Ketamine Infusion Therapy

Four Conditions Treated Successfully with Ketamine Infusion Therapy

Ketamine infusion therapy is a relatively new treatment option for mental health disorders and chronic pain. Initially used as an anesthetic in the medical field, Ketamine has been shown to provide relief from a range of conditions such as depression, PTSD, anxiety, and chronic pain. Below we will discuss the benefits of Ketamine infusion therapy in treating these conditions.


Depression is a mood disorder that affects millions of people worldwide. Traditional antidepressants can take weeks to show any effect, and a significant percentage of patients do not respond to these medications at all. Ketamine infusion therapy has emerged as a promising treatment option for depression, especially for those who are resistant to traditional antidepressants. Ketamine acts on the glutamate system in the brain, leading to the release of a chemical called BDNF (brain-derived neurotrophic factor), which promotes the growth and survival of brain cells. This mechanism of action is different from traditional antidepressants, which work by altering serotonin and other neurotransmitter levels. Ketamine infusion therapy can improve depressive symptoms within hours, which is a significant advantage over conventional antidepressants. Additionally, studies have shown that the effects of Ketamine infusion therapy can last up to several weeks, with some patients experiencing relief from depression for months.


PTSD (Post Traumatic Stress Disorder) is a condition that affects individuals who have experienced or witnessed traumatic events such as sexual assault, combat, or natural disasters. PTSD can manifest as intrusive thoughts, nightmares, flashbacks, and hypervigilance, among other symptoms. Traditional treatments for PTSD include psychotherapy and medications such as selective serotonin reuptake inhibitors (SSRIs). However, these treatments do not work for everyone, and some patients may not respond to them. Ketamine infusion therapy has been shown to be effective in treating PTSD, especially in those who have not responded to traditional treatments. Ketamine has been found to increase the production of a protein called mTOR, which is involved in the formation and strengthening of synapses in the brain. This process may help to overwrite traumatic memories and reduce the symptoms of PTSD.


Anxiety disorders are the most common mental health disorders in the United States, affecting approximately 40 million adults. These disorders can manifest as excessive worry, fear, and panic attacks, among other symptoms. Traditional treatments for anxiety disorders include psychotherapy and medications such as benzodiazepines and SSRIs. However, these treatments have their limitations, and not all patients respond to them. Ketamine infusion therapy has shown promise in treating anxiety disorders, especially in those who have not responded to traditional treatments. Ketamine works by blocking the N-methyl-D-aspartate (NMDA) receptor in the brain, which is involved in regulating anxiety. This blocking effect can reduce the symptoms of anxiety and provide relief to patients.

Chronic Pain

Chronic pain is a condition that affects millions of people worldwide and can be debilitating. Traditional treatments for chronic pain include medications such as opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), and physical therapy. However, these treatments can have significant side effects and may not provide relief to all patients. Ketamine infusion therapy has emerged as a promising treatment option for chronic pain, especially in those who have not responded to traditional treatments. Ketamine acts on the NMDA receptor in the brain, which is involved in the perception of pain. By blocking this receptor, Ketamine can reduce the perception of pain and provide relief to patients.

In addition to the benefits discussed above, Ketamine infusion therapy has several other advantages over traditional treatments. Ketamine infusion therapy is administered intravenously, which allows for precise dosing and rapid onset of action. In addition, patients can start feeling the effects of Ketamine infusion therapy within hours of treatment, which is a significant advantage over traditional medicines, which can take weeks to months.

To learn more about this innovative treatment, click here or call 505-639-4973

Man sleeping and working

The Connection Between Mental Health and Sleep

The more we learn about sleep, the more we realize it is the foundation for health and wellness. For many years, mental health issues such as depression, PTSD, and anxiety have been pinpointed as the cause of poor sleep. However, recent research shows that it could be the other way around in some cases! Lack of consistent sleep could be the cause of some mental health issues.

Let’s look at depression. An analysis of 21 different studies found that people who suffer from insomnia have twice the probability of developing depression compared to those who do not have problems sleeping. 

Research around anxiety had similar conclusions. Insomnia appeared to be a risk factor for developing anxiety disorders. One of these studies concluded that problems with sleep were a predictor for generalized anxiety disorder in children and teens between the ages of nine and 16.9 Additionally, those who struggle with sleep problems may be more likely to develop an anxiety condition, particularly if their sleep problems are prolonged and left untreated.

What about PTSD? Sleep deprivation is not only a common symptom of post-traumatic stress disorder (PTSD) affecting between 80% to 90% of people with the condition but it is also believed to play a role in both the development and maintenance of this disorder.

These are just a few examples of how sleep, or lack thereof, can impact mental health. For this reason, we recommend that our patients undergoing Ketamine Infusion Therapy treatments do their best to improve the quality of their sleep each night. Here are our top tips:

Natural Light Exposure In The Mornings

Exposure to natural sunlight in the morning helps us regulate our natural circadian rhythms, also known as our natural body clock. Our circadian rhythm tells us when to go to bed, wake, eat, and even when to release mood-altering hormones. So, in addition to the sleep benefit, it will boost your immune system, lower stress, and regulate your appetite!

No Caffeine 12 Hours Before Bedtime

Many of us love our morning joe, but consuming it too late in the day can impact our sleep. As a rule of thumb, we have found that by giving yourself a 12-hour window of no caffeine, sleep improves significantly! So, for example, if you want to go to bed by 10 pm, don’t consume caffeine after 10 am that day.

Avoid Screens Before Bedtime

Minimizing screen time at night is an excellent tip for a few reasons. First, exposing your eyes to light before you try to go to sleep disturbs your circadian rhythm (see the sun exposure tip above). It tricks your mind into thinking you are starting your day rather than ending it. In addition, our screens are often TVs, smartphones, or ipads where we are taking in information such as news, or work emails, which could cause added stress, making it difficult to sleep. Try reading or listening to music as an alternative.

While sleep isn’t the only answer to mental health issues, it is a considerable component that we are discovering more and more about how important it is for overall wellness. So whether you are undergoing treatment of any kind for any mental health condition or not, improving your sleep is the path to elevating your overall physical and mental health.

To learn more about Ketamine Infusion Therapy, click here or call 505-639-4973


Suicidal Ideation And Ketamine Infusion Therapy

Bringing awareness to this often-stigmatized topic is key to ensuring those who suffer from suicidal ideation can find the right resources to help them. Suicide continues to be a leading cause of death worldwide, yet few treatments are available to lessen the risk. As a clinic that specializes in treating Major Depressive Disorder, anxiety, and PTSD, this subject is crucial to us.


What Are The Statistics?

Death by suicide has been on the rise for over a decade. According to the World Health Organization, an estimated 703,000 people a year take their life worldwide. For every suicide, there are likely 20 other people making a suicide attempt, and many more have serious thoughts of suicide. Men are more likely to die by suicide 3.6 times more often than women; however, women were 1.4 times more likely to attempt it. Also surprising, suicide is the 2nd leading cause of death for ages 10-34 and the 4th leading cause of death for ages 35-54. Suicide rates amongst men aged 15-24 experienced the most significant increase this past year at a staggering 8%.


Diagnosing Suicidal Ideation

An underlying mental health issue often lays the foundation for suicidal ideation. For others, alcohol or substance abuse can play a role in suicidal thoughts. In some cases, suicidal thinking can be related to an underlying physical health problem, and blood tests or other medical tests may be necessary to diagnose. Recently, research has highlighted how stress is often a precipitating factor overlooked in the literature. In any of the above situations, contacting a health professional is necessary to work through the cause of such thoughts.


What Are The Treatments?

For non-emergency situations, many traditional outpatient treatments are available for those with suicidal ideation. Psychological counseling can help explore the issues that led to suicidal thoughts and help learn skills to manage emotions. Medications are often prescribed, such as antidepressants, anti-psychotic drugs, anti-anxiety medications, etc., to help reduce symptoms. Addiction treatment can also aid those whose suicidal ideation stems from substance abuse.


Ketamine Infusion Therapy

Traditional therapies sometimes don’t provide the relief needed to recover from suicidal thoughts. Prescription medications can take weeks or months to take effect, and the efficacy is variable and often incomplete. As a result, 66% of patients suffer treatment-resistant depression and endure months of trial treatments and adjunctive therapies in hopes of relief.

 Ketamine infusion therapy has proven to be rapidly effective in the remission of depressive symptoms of MDD, TDD, and BD, in some cases providing temporary relief within hours of the first infusion. It is remarkably effective in aborting suicidal ideations with a single IV infusion. Ketamine has been shown to be 70% effective in TDD. According to a review published in ScienceDirect, “recent findings from human and animal research (are) demonstrating rapid-acting mechanisms via which ketamine effectively rescues stress-induced pathologies linked to suicide risk.” In addition, they also discovered additional impacts on clinical risk factors: ketamine improves mood, sleep, and reward processing

Although the response to a single infusion is short-lived (a matter of days), repeat administration over a short time (typically two weeks) can extend the length of remission, with some patients enjoying improvement for as long as six months. Additional “booster” treatments can be given that continually expand the duration of remission of symptoms. Ketamine infusions are safe, rapid, and effective. Consequently, ketamine infusion therapy is revolutionizing the treatment of depressive disorders.


If you or someone you know is having suicidal thoughts, call The National Suicide Prevention Lifeline at 800-273-TALK (8255) or call 911 immediately. If you are interested in exploring Ketamine Infusion Therapy to treat suicidal ideation or depression, call our clinic at 505-639-4973 or click here.